Abstract

Murine leukemia viruses (MuLVs) are the prototypical gammaretroviruses, and they have been extensively studied with regard to how they cause disease. Leukemogenesis by two MuLVs is reviewed here: the endogenous Akv MuLV of AKR mice, and exogenous Moloney MuLV. Important features of MuLV leukemogenesis include the in vivo generation of envelope recombinants (MCFs) through recombination with endogenous MuLVs, and induction of preleukemic changes typified by splenic hyperplasia secondary to bone marrow defects. Studies of MuLV leukemogenesis help to frame virological questions about how koala retrovirus (KoRV) may induce neoplastic or other diseases in koalas.

 
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Bibliographic Data

Short Form
Fan, 2014. Tech. Rep. Aust. Mus., Online 24: 83–88
Author
Hung Fan
Year
2014
Title
Leukemogenesis by murine leukemia viruses: lessons for koala retrovirus (KoRV)
Serial Title
Technical Reports of the Australian Museum, Online
Volume
24
Start Page
83
End Page
88
DOI
10.3853/j.1835-4211.24.2014.1622
Language
English
Date Published
30 May 2014
Cover Date
30 May 2014
ISSN
1835-4211 (online)
Publisher
The Australian Museum
Place Published
Sydney, Australia
Subjects
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized
30 May 2014
Available Online
30 May 2014
Reference Number
1622
EndNote
/Uploads/Journals/30995/1622.enw
Title Page
/Uploads/Journals/30995/1622.pdf
File size: 167kB
Complete Work
/Uploads/Journals/30995/1622_complete.pdf
File size: 449kB