Abstract

Although koala retrovirus (KoRV) is widely termed a pathogen, direct evidence for causation of disease impacts in koalas (Phascolarctos cinereus) remains elusive. Examination of the immune system of koalas could provide a sharper tool to investigate this but progress has been slow due to a paucity of immunological reagents in this species, and historical contradictions in research findings in this area. Our work using cross reactive antibodies to examine behaviour of resting and stimulated koala T cells (anti-human CD3); B cells (anti-human CD79b); MHCII (anti-human HLA-DP, DQ, DR) and interferon gamma (anti-bovine IFNg) by flow cytometry have revealed some features consistent with a skew to a Th2 (B cell) immune focus. Assessing the role of KoRV in immunomodulation in koalas clearly requires more in-depth research. We have used recent advances in genomics of other marsupials to develop tools necessary to assess KoRV’s effects on koala immune function in free-ranging, captive and in-vitro systems.

 
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Bibliographic Data

Short Form
Higgins et al., 2014. Tech. Rep. Aust. Mus., Online 24: 35–38
Author
Damien P. Higgins; Quintin Lau; Iona Maher
Year
2014
Title
Koala immunology and the koala retrovirus (KoRV)
Serial Title
Technical Reports of the Australian Museum, Online
Volume
24
Start Page
35
End Page
38
DOI
10.3853/j.1835-4211.24.2014.1611
Language
English
Date Published
30 May 2014
Cover Date
30 May 2014
ISSN
1835-4211 (online)
Publisher
The Australian Museum
Place Published
Sydney, Australia
Subjects
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized
30 May 2014
Available Online
30 May 2014
Reference Number
1611
EndNote
/Uploads/Journals/30984/1611.enw
Title Page
/Uploads/Journals/30984/1611.pdf
File size: 168kB
Complete Work
/Uploads/Journals/30984/1611_complete.pdf
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