Abstract

The presence of multiple retroviruses in koalas (Phascolarctos cinereus), including viruses with exogenous infectious forms that may be associated with malignant disease manifestations, poses challenges for both management of captive populations and species preservation in the wild. The development of antiretroviral medications (ARV) for the treatment of human immunodeficiency virus (HIV) infection is one of the triumphs of modern medicine, and many of these drugs have relatively broad antiretroviral activity, suggesting they might be active against koala retroviruses (KoRVs). However, accumulating experience with the use of these medications in non-human primate (NHP) models of HIV infection and acquired immune deficiency syndrome (AIDS) points out several caveats and provides guidance in attempting to use anti-HIV drugs in the treatment of retroviral infection in nonhuman species. This manuscript reviews that experience from the perspective of potential use of ARVs for prevention and treatment of KoRV infection.

 
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Bibliographic Data

Short Form
Lifson, 2014. Tech. Rep. Aust. Mus., Online 24: 65–69
Author
Jeffrey D. Lifson
Year
2014
Title
Prevention and treatment of koala retrovirus (KoRV) infection: lessons from studies of AIDS viruses in nonhuman primate models
Serial Title
Technical Reports of the Australian Museum, Online
Volume
24
Start Page
65
End Page
69
DOI
10.3853/j.1835-4211.24.2014.1619
Language
English
Date Published
30 May 2014
Cover Date
30 May 2014
ISSN
1835-4211 (online)
Publisher
The Australian Museum
Place Published
Sydney, Australia
Subjects
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized
30 May 2014
Available Online
30 May 2014
Reference Number
1919
EndNote
/Uploads/Journals/30992/1619.enw
Title Page
/Uploads/Journals/30992/1619.pdf
File size: 161kB
Complete Work
/Uploads/Journals/30992/1619_complete.pdf
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