Abstract

There are two main infectious disease threats for the koala; Chlamydia and KoRV. A major question is whether or not KoRV predisposes koalas to more severe chlamydial disease. In the only study to date that has examined co-infections, KoRV load (as determined by qPCR) and chlamydial load (as determined by qPCR) and chlamydial disease were examined in wild koalas. While there was a statistically significant correlation between Chlamydia infection load and Chlamydia clinical disease score, there was no significant correlation between KoRV load and either Chlamydia infection load or Chlamydia clinical disease score, however the groups were not ideally constructed and hence additional comparisons are needed. If KoRV does predispose koalas to more severe chlamydial disease, one would expect it to do this via an effect on the koala immune system. A series of Chlamydia vaccine trials in captive as well as wild koalas are showing that koalas in fact appear to make perfectly normal antibody and cytokine responses to vaccine antigens, even if they have high circulating KoRV loads, arguing against an immune suppressive effect by KoRV.

 
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Bibliographic Data

Short Form
Timms, 2014. Tech. Rep. Aust. Mus., Online 24: 89–90
Author
Peter Timms
Year
2014
Title
KoRV and Chlamydia: are they co-culprits?
Serial Title
Technical Reports of the Australian Museum, Online
Volume
24
Start Page
89
End Page
90
DOI
10.3853/j.1835-4211.24.2014.1623
Language
English
Date Published
30 May 2014
Cover Date
30 May 2014
ISSN
1835-4211 (online)
Publisher
The Australian Museum
Place Published
Sydney, Australia
Subjects
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized
30 May 2014
Available Online
30 May 2014
Reference Number
1623
EndNote
/Uploads/Journals/30996/1623.enw
Title Page
/Uploads/Journals/30996/1623.pdf
File size: 163kB
Complete Work
/Uploads/Journals/30996/1623_complete.pdf
File size: 310kB