Abstract

The findings of an exogenous koala retrovirus (KoRV) associated with neoplastic diseases in koalas (Phascolarctos cinereus) brought up the concerns of infection by koala retroviruses in humans, especially koala handlers. As simple retroviruses, koala retroviruses lack the regulatory genes to counter restriction activities by human restriction factors in viral replication. Koala retroviruses belong to gammaretroviruses. Previous studies of susceptibility of murine leukemia virus and a lab contaminant retrovirus, gammaretroviral xenotropic MLV-related virus, to human restriction factors disprove the possibility of gammaretrovirus as a human pathogen. There is no evidence that the koala retrovirus can infect and replicate in human peripheral blood mononuclear cells, which is consistent with the resistant role of human restriction factors against gammaretroviruses.

 
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Bibliographic Data

Short Form
Xu et al., 2014. Tech. Rep. Aust. Mus., Online 24: 79–81
Author
Wenqin Xu; Tiffany Blankenship; Maribeth V. Eiden
Year
2014
Title
Potential role of human restriction factors in inhibiting the emergence of koala retrovirus (KoRV) as a zoonotic agent
Serial Title
Technical Reports of the Australian Museum, Online
Volume
24
Start Page
79
End Page
81
DOI
10.3853/j.1835-4211.24.2014.1621
Language
English
Date Published
30 May 2014
Cover Date
30 May 2014
ISSN
1835-4211 (online)
Publisher
The Australian Museum
Place Published
Sydney, Australia
Subjects
RETROVIRUS; ANIMAL DISEASE; VIROLOGY; MAMMALIA: MARSUPIALIA
Digitized
30 May 2014
Available Online
30 May 2014
Reference Number
1621
EndNote
/Uploads/Journals/30994/1621.enw
Title Page
/Uploads/Journals/30994/1621.pdf
File size: 164kB
Complete Work
/Uploads/Journals/30994/1621_complete.pdf
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